{"ATC Code":["N - Nervous system","N01 - Anesthetics","N01A - Anesthetics, general","N01AA - Ethers","N01AA01 - Diethyl ether","QN - Nervous system","QN01 - Anesthetics","QN01A - Anesthetics, general","QN01AA - Ethers","QN01AA01 - Diethyl ether"],"Abbreviation":["Ether"],"Absorption, Distribution and Excretion":"After inhalation, ethyl ether is rapidly transferred from alveoli to blood. The normal alveolar membrane poses no barrier to the transfer of ethyl ether in either direction. The blood/gas distribution coefficient of ethyl ether is high - 12.1. For oil/gas, the distribution coefficient is 65. ...The penetration /of ethyl ether/ in rabbit skin /was studied/. ... Doses over 20 mL/kg bw could not be retained in contact with the skin. ... The single dermal penetration LD50 was greater than 20 mL/kg bw.","Adverse Effects":"Neurotoxin - Acute solvent syndrome","Aliases":["Diethyl Ether","ether","Ethyl ether","Ethoxyethane","Ethyl oxide","Pronarcol","Diethyl oxide","Aether","Anesthetic ether","Anaesthetic ether","Solvent ether","3-Oxapentane","Ether, ethyl","Diaethylaether","Dwuetylowy eter","Etere etilico","Ether ethylique","Anesthesia ether","Oxyde d'ethyle","1,1'-Oxybisethane","Ethane, 1,1'-oxybis-","Diethylaether","1,1'-oxydiethane","Ethyl ether, tech.","Sulfuric ether","Etherum","RCRA waste number U117","Ether, Diethyl","Ether anaesthesicus","NSC-100036","Chebi:35702","NSC100036","Dtxcid101720","Chebi:25698","200-467-2","Diethylether","aether pro narcosi","NSC 100036","Mfcd00011646","(C2H5)2O","SCHEMBL6","Ether","667919-88-2","HSDB 70","Et2O","Ether, anhydrous","Einecs 200-467-2","UN1155","RCRA waste no. U117","dietylether","Diethyether","di ethylether","di-ethylether","diehtyl ether","diethyl-ether","ether anhydrous","ethoxy-ethane","monoethyl ether","Anhydrous ether","diethl ether","diethy ether","dietyl ether","ehtyl ether","ethyl-ether","diethyI ether","2-ethoxyethane","AI3-24233","di ethyl ether","di-ethyl ether","ethyl ether-","EtOEt","1-Ethoxyethane #","Ethane,1'-oxybis-","1,1' -oxybisethane","1,1'-oxy-bisethane","1,1'-oxybis ethane","OEt2","1,1'-oxobis(ethane)","ETHER","SCHEMBL209","Ec 200-467-2","Schembl2487","Schembl2588","O(Et)2","Diethyl ether or ethyl ether","Diethyl ether, \u003e=99.5%","Chembl16264","Schembl385743","Schembl385744","Ethyl ether anhydrous A.C.S.","O(CH2CH3)2","Schembl3140144","Schembl3456882","Schembl4120442","Schembl4764802","Schembl8966068","WLN: 2O2","Isopropyl Alcohol EP Impurity D","Diethyl ether, p.a., 99.0%","Diethyl ether, p.a., 99.5%","Diethyl ether, analytical standard","O(C2H5)2","Diethylether (Peptide Grade), 99%","Akos015950740","Diethyl ether, ACS reagent, 99.5%","DB13598","Diethyl ether, Spectrophotometric Grade","UN 1155","Diethylether 100 microg/mL in Acetonitrile","D3479","Diethyl ether, SAJ first grade, \u003e=99.0%","NS00001638","Diethyl ether, JIS special grade, \u003e=99.5%","D01772","Diethyl ether, UV HPLC spectroscopic, 99.9%","Diethyl ether, anhydrous, 99.5%, ?50 ppm H2O","Ethyl ether anhydrous stabilized with 5ppm of BHT","Diethyl ether, Laboratory Reagent, \u003e=99.5%","Diethyl ether, for HPLC, \u003e=99.9%, inhibitor-free","Diethyl ether, for UV-spectroscopy, \u003e=99.8%","InChI=1/C4H10O/c1-3-5-4-2/h3-4H2,1-2H","1-hydroperoxy-8-carboxyoctyl 3,4-epoxynon-(2E)-enyl ether","Diethyl ether or ethyl ether [UN1155] ","Diethyl ether, anhydrous, ACS, 99% min, stab. with BHT","Diethyl ether, puriss., 99.0%, contains 0.0025% BHT","Diethyl ether anhydrous ACS grade stabilized with 5ppm of BHT","Diethyl ether, puriss. p.a., ACS reagent, \u003e=99.8%","Diethyl ether, Spectrophotometric Grade, 99%, inhibitor free","Ethyl ether, anhydrous, stabilized with BHT, Max water 50ppm","Diethyl ether, AR, contains 5 ppm BHT as stabilizer, \u003e=99.5%","Diethyl ether, for HPLC, contains 5 ppm BHT as stabilizer, \u003e=99%","Diethyl ether, LR, contains 5 ppm BHT as stabilizer, \u003e=99.5%","Diethyl ether, p.a., ACS reagent, 99.5%, contains 0.0025% BHT","Diethyl ether, spectrophotometric grade, \u003e=99.9%, inhibitor-free","Diethyl ether, ACS reagent, anhydrous, \u003e=99.0%, contains BHT as inhibitor","Diethyl ether, anhydrous, ACS reagent, \u003e=99.0%, contains BHT as inhibitor","Diethyl ether, anhydrous, contains 5 ppm BHT as stabilizer, \u003e=99.5%","Diethyl ether, contains 1 ppm BHT as inhibitor, anhydrous, \u003e=99.7%","Diethyl ether, ACS reagent, \u003e=98.0%, contains ~2% ethanol and ~10ppm BHT as inhibitor","Diethyl ether, anhydrous, ACS reagent, \u003e=99.0%, contains 1 ppm BHT as inhibitor","Diethyl Ether, Pharmaceutical Secondary Standard; Certified Reference Material","Diethyl ether, puriss., dried over molecular sieve (H2O \u003c=0.005%), \u003e=99.8%","Diethyl ether, puriss., meets analytical specification of Ph.??Eur., BP, \u003e=99.5%","Diethyl ether, reagent grade, \u003e=98%, contains ~2% ethanol and ~10ppm BHT as inhibitor","Diethyl ether, contains BHT as inhibitor, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., \u003e=99.8%"],"Associated Disorders and Diseases":"Solvents, acute toxic effect [Category: Acute Poisoning]","Boiling Point":"94.3 °","CAS":"60-29-7","Chemical Classes":"Flammable agents - 4th degree","ChemicalClasses":["ether"],"Chirality":"achiral","Color/Form":"Colorless, volatile, mobile liquid","DTXSID":"3021720","Decomposition":"When heated to decomposition it emits acrid smoke and irritating fumes.","Density":"0.714 at 68 °F (USCG, 1999) - Less dense than water; will float g/cm\u003csup\u003e3\u003c/sup\u003e","Drug Warnings":"Main contraindications to ether anesthesia are acute and chronic respiratory diseases and advanced renal disease.","Ecotoxicity Values":"LC50 Poecilia reticulata (guppy) 2134 mg/L for 14 days; semistatic, 22 °C","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"200-467-2","Flash Point":"-49 °F (NTP, 1992)","Formating":[],"HMDB ID":"HMDB0062326","Health Effects":"Diethyl ether causes CNS depression. Death due to respiratory depression may result from severe and prolonged exposure. (T36)","HeavyAtomCount":5,"IUPACName":"ethoxyethane","Impurities":"USP/ACS grade typically containing 2% alcohol; anhydrous grade typically containing 0.003% water and less than 0.01% alcohol.","InChI":"InChI=1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3","InChIKey":"RTZKZFJDLAIYFH-UHFFFAOYSA-N","Interactions":"The disposition of diflunisal (DF) at 10 mg/kg iv was investigated over 4 hr in bile-exteriorized male rats continuously anaesthetized with ...  diethyl ether inhalation (as required) ... and compared to that obtained in conscious rats. 2. Diethyl ether decreased the plasma clearance of DF to about 30% of control values, by inhibition of both glucuronidation and sulfation of DF. ...","MeSH Headers":[{"Id":"M0007827","Link":"https://id.nlm.nih.gov/mesh/M0007827.html","Name":"Ether","Ref":115},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":117},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":147},{"Id":"M0020141","Link":"https://id.nlm.nih.gov/mesh/M0020141.html","Name":"Solvents","Ref":148},{"Id":"M0027998","Link":"https://id.nlm.nih.gov/mesh/M0027998.html","Name":"Anesthetics, Inhalation","Ref":149}],"MeSH Pharmacological Classification":[{"Id":"M0020141","Link":"https://id.nlm.nih.gov/mesh/M0020141.html","Name":"Solvent","Ref":148},{"Id":"M0027998","Link":"https://id.nlm.nih.gov/mesh/M0027998.html","Name":"Anesthetics, Inhalation","Ref":149}],"Mechanism of Action":"The mechanism of action by which .... ethyl ether produce/s/ reversible loss of consciousness is still unclear. Anesthesia can be produced  by a wide variety of chemical agents, ranging from inert rare gases to steriodal molecules. This apparent lack of specificity, together with the observation that general anesthesia can be reversed by high pressure, poses a unique pharmacological problem. Most theories concern interaction of anesthetics with either membrane lipids or hydrophobic regions of specificic membrane-bound proteins. One hypothesis is that the anesthetic changes the function of an ion channel protein by modifying the conformation of the protein. Some investigators suggest that the GABA receptor may be the ion channel protein that is affected by inhalation of anesthetic agents... The most appropriate concept for the mechanism of general anesthesia /may be/ a the heterogenous site of anesthetic action, including both lipid and protein membrane components linked with neuronal function.","Melting Point":"-177.3 °F (NTP, 1992)","Metabolism/Metabolites":"It has been estimated that about 8-10% of absorbed ethyl ether is metabolized in the body whereas the remainder is excreted unchanged through the lungs. Ethyl ether is metabolized to ethanol and acetaldehyde by the inducible hepatic microsomal enzyme system, a cytochrome P450-containing monooxygenase system. Ethanol and acetaldehyde are rapidly oxidized to acetate, and the acetate subsequently enters the 2-carbon pool of intermediary metabolism.","MolecularFormula":"C\u003csub\u003e4\u003c/sub\u003eH\u003csub\u003e10\u003c/sub\u003eO","MolecularWeight":"74.12 g/mol","Non-Human Toxicity Values":"LD50 Mouse iv 996 mg/kg bw","Odor":"Sweetish, pungent odor","Physical Description":"Diethyl ether appears as a clear colorless liquid with an anesthetic odor. Flash point -49 °F. Less dense than water and slightly soluble in water. Hence floats on water. Vapors are heavier than air. Used as a solvent and to make other chemicals.","PubChemId":3283,"PubChemTitle":"Diethyl Ether","Records":{"UNII":{"Impurities":[]}},"Reddit Experience Reports":[],"RefChem":"6635","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Diethyl ether","Name":"Diethyl ether","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q202218","Name":"Diethyl ether","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB13598","Name":"Diethyl ether","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3283","Name":"Diethyl ether","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=60-29-7","Name":"Diethyl ether","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0062326","Name":"Diethyl ether","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D01772","Name":"Diethyl ether","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/0F5N573A2Y","Name":"Diethyl ether","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021720","Name":"Diethyl ether","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3283, Diethyl ether. Accessed August 24, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3283\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3283\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Diethyl ether. UNII: 0F5N573A2Y. Global Substance Registration System. Accessed August 24, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/0F5N573A2Y\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/0F5N573A2Y\u003c/a\u003e"],"Reported Fatal Dose":"Blood level: ... Lethal= 1400-1890 ug/mL","SMILES":"CCOCC","SaltData":[],"Salts":[],"Solubility":"greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)","Stability/Shelf Life":"It is slowly oxidized by action of air, moisture, and light, with formation of peroxides.","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 55.006 11.879\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".8\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h56v12H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m53.899 8.726-13.198-7.62M40.701 1.106l-9.59 5.537M23.895 6.643l-9.59-5.537M14.305 1.106 1.106 8.726\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M27.506 6.682q-.738 0-1.173.553-.428.548-.428 1.494 0 .947.428 1.495.435.547 1.173.547t1.167-.547.428-1.495q0-.946-.428-1.494-.429-.553-1.167-.553m0-.548q1.054 0 1.679.708.631.703.631 1.887 0 1.179-.631 1.888-.625.702-1.679.702t-1.685-.702-.631-1.888q0-1.184.631-1.887.631-.708 1.685-.708\" class=\"atom\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m31.111 6.643 4.795-2.769M23.895 6.643 19.1 3.874\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Taste":"Burning and sweet taste","Therapeutic Uses":"Anesthetics, Inhalation; Solvents","Title":"Diethyl ether","Toxicity Data":"LCLo (rat) = 32,000 ppm/4h","Treatment":"There is no antidote for diethyl ether poisoning, thus treatment is symptomatic and supportive. (T36)","UNII":"0F5N573A2Y","Wikidata":"Q202218","Wikipedia":"Diethyl ether","XLogP":0.9}